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All whole exome sequencing raw data were deposited in NCBI Sequence Read Archive (SRA) and are accessible through project numbers PRJNA1283526

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VSMC proliferation and intimal thickening also predispose individuals to oscillatory or low blood flow, which have been shown to induce leukocyte adhesion, enhanced vascular permeability, LDL oxidation, and atherosclerotic plaque formation 42,43,44

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